Effect Of Methanol Leaf Extract Of Annona muricata On Renal And Liver Function Indices In Dihydrotestosterone-Estradiol Valerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats
Abstract
Benign
prostatic hyperplasia (BPH) is a progressive noncancerous enlargement of the
epithelial cells and smooth muscle ofthe prostate gland accompanied by lower
urinary tract symptoms (Parsons and Kashefi, 2008).Benign prostatic hyperplasia
(BPH) is a common cause of significant lower urinary tract symptoms (LUTS) in
men and the most common cause of bladder outflow obstruction in men aged above
70 years (Lowe, 1999). BPH affects, to variable degrees, both glandular
epithelium and connective tissue stroma of the prostate. The etiology is not
clearly understood and is probably multifactorial, but it is well recognized
that the condition is related to the aging process and androgenic influence
(Dhingra and Bhagawat, 2011). The complications of BPH include frequency of
micturition, nocturia, dysuria and urgency or urge incontinence. Acute
retention of urine is an unfortunate obstructive complication. Surgery is the
ultimate solution, but pharmacotherapy is often tried first and continued for
as long as feasible (Sengupta et al., 2011). The allopathic medicines used in
the treatment ofBPH are associated with a number ofside effects (eg.
Finasteride shows sexual complaints like erectile dysfunction) and
post-surgical complications are more with the surgical procedures like
Prostatectomy (Dhingra and Bhagawat, 2011).
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AMARACHI, C (2023). Effect Of Methanol Leaf Extract Of Annona muricata On Renal And Liver Function Indices In Dihydrotestosterone-Estradiol Valerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats. Repository.mouau.edu.ng: Retrieved Nov 25, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-renal-and-liver-function-indices-in-dihydrotestosterone-estradiol-valerate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-7-2
CLARA, AMARACHI. " Effect Of Methanol Leaf Extract Of Annona muricata On Renal And Liver Function Indices In Dihydrotestosterone-Estradiol Valerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 16 Oct. 2023, https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-renal-and-liver-function-indices-in-dihydrotestosterone-estradiol-valerate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-7-2. Accessed 25 Nov. 2024.
CLARA, AMARACHI. " Effect Of Methanol Leaf Extract Of Annona muricata On Renal And Liver Function Indices In Dihydrotestosterone-Estradiol Valerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 16 Oct. 2023. Web. 25 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-renal-and-liver-function-indices-in-dihydrotestosterone-estradiol-valerate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-7-2 >.
CLARA, AMARACHI. " Effect Of Methanol Leaf Extract Of Annona muricata On Renal And Liver Function Indices In Dihydrotestosterone-Estradiol Valerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats" Repository.mouau.edu.ng (2023). Accessed 25 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-renal-and-liver-function-indices-in-dihydrotestosterone-estradiol-valerate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-7-2