Effect Of Methanol Leaf Extract Of Annona Muricata On Antioxidant Enzymes In Dihydrotesterone Estradiol Valerate To Induced Benign Prostatic Hyperplasia In Male Albino Rats:- Chikezie, Charles I.
ABSTRACT
The
phytochemical content of Annona muricata leaves and the effect of methanol
extract on antioxidant enzymes were investigated using standard methods. The
phytochemical analysis showed the presence of flavonoids, saponins, tannin,
alkaloids and terpenes. The acute toxicity result was estimated at 5000mg/kg
bwt of extract which showed high level of safety. Progressive weight gain was
observed in all the groups with the normal control group (49.11%) having the
highest percentage weight gain. The result of the relative prostate weight
increased (P<0.05) significantly in the disease control when compared with
other treatment groups while the relative testes weight decreased (P<0.05)
significantly in disease control groups relative to other treatment groups and
normal control. Prostatic specific antigen(PSA) level significantly
(P<0.05) decreased in the treatment groups compared to the negative control
(disease control) with the extract treated exhibiting more effectiveness with
dose. The levels of catalase, GSH, GPX and SOD level significantly (P<0.05)
. increased in the treatment groups compared with the disease control. The
result showed that the extract reduced the prostate weight and the PSA levels
of BPH induced rats, thus can be used in the management of BPH. This
pharmacological activity of methanol extract of Annona muricata may be
attributed to the presence of phytochemical agents observed in the leaves.
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CHIKEZIE, I (2023). Effect Of Methanol Leaf Extract Of Annona Muricata On Antioxidant Enzymes In Dihydrotesterone Estradiol Valerate To Induced Benign Prostatic Hyperplasia In Male Albino Rats:- Chikezie, Charles I.. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-antioxidant-enzymes-in-dihydrotesterone-estradiol-valerate-to-induced-benign-prostatic-hyperplasia-in-male-albino-rats-chikezie-charles-i-7-2
IKENNA, CHIKEZIE. "Effect Of Methanol Leaf Extract Of Annona Muricata On Antioxidant Enzymes In Dihydrotesterone Estradiol Valerate To Induced Benign Prostatic Hyperplasia In Male Albino Rats:- Chikezie, Charles I." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 31 Oct. 2023, https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-antioxidant-enzymes-in-dihydrotesterone-estradiol-valerate-to-induced-benign-prostatic-hyperplasia-in-male-albino-rats-chikezie-charles-i-7-2. Accessed 24 Nov. 2024.
IKENNA, CHIKEZIE. "Effect Of Methanol Leaf Extract Of Annona Muricata On Antioxidant Enzymes In Dihydrotesterone Estradiol Valerate To Induced Benign Prostatic Hyperplasia In Male Albino Rats:- Chikezie, Charles I.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 31 Oct. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-antioxidant-enzymes-in-dihydrotesterone-estradiol-valerate-to-induced-benign-prostatic-hyperplasia-in-male-albino-rats-chikezie-charles-i-7-2 >.
IKENNA, CHIKEZIE. "Effect Of Methanol Leaf Extract Of Annona Muricata On Antioxidant Enzymes In Dihydrotesterone Estradiol Valerate To Induced Benign Prostatic Hyperplasia In Male Albino Rats:- Chikezie, Charles I." Repository.mouau.edu.ng (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-antioxidant-enzymes-in-dihydrotesterone-estradiol-valerate-to-induced-benign-prostatic-hyperplasia-in-male-albino-rats-chikezie-charles-i-7-2