Effect Of Methanol Leaf Extract Of Annona Muricata On Anti-Inflammatory Parameters In Dihydrotestosterone-Estradiolvalerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Oguoyibo Josephine S

Oguoyibo Josephine Sisan | 64 pages (11898 words) | Projects

ABSTRACT

The objectives ofthis study was to examine the phytochemical constituent, acute toxicity and anti-inflammatory activities of the leaf extract of annona muricata in dihydrotestosteroneestradiol valerate induced benign prostatic hyperplasia in male wistar albino rats .The disease was induced using dihydrotestosterone and estradiol valerate in a ratio 10:1; twenty rats were used and kept in five groups, the experiment lasted for twenty eight days. The first group was called the normal control group and was not induced with the hormone DHT but received oral and subcutaneous administration of olive oil for twenty-eight days of the experiment. The second group was the disease control group, which received subcutaneous injection of 9mg/kg body weight of dihydrotestosterone , 0.9mg/kg body weight estradiol-valerate and oral administration of pure olive oil every day for 28 days. The third group, the drug control group received subcutaneous injection of 9mg/kg body weight of dihydrotestosterone, 0.9mg/kg body weight estradiol-valerate and oral administration of 5mg/70kg finasteride every day. The fourth group received received subcutaneous injection of 9mg/kg body weight of dihydrotestosterone and 0.9mg/kg body weight estradiol valerate every other day for 28 days and oral administration of 200mg of Annona Muricata every other for 28 days, while the fifth group received subcutaneous injection of 9mg/kg body weight of Dihydrotestosterone (DHT) and 0.9mg/kg body weight estradiol valerate every day for 28days and oral administration of 400mg Annona Muricata.The result of the phytochemical analysis showed the presence of flavonoid,saponins,tanins and phenol. The acute toxicity studies showed that the extract is safe at maximum dose of 2250mg 1kg bwt of tire extract. The result also showed significant (p<0.05) increases in the levels of C-reactive proteimPSA and relative prostate weight in disease control in relation to other treatment group. There was no significant (p>0.05) difference in creatine kinase.Methanol leaf extracts of Annona muricata shows its ability to reduce prostate size,C-reactive protein level and a moderate increase in the body weight of the rats. It also showed anti-inflammatory activities which could be attributed to the presence offlavonoids, saponins, tannins and phenols.

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APA

OGUOYIBO, S (2024). Effect Of Methanol Leaf Extract Of Annona Muricata On Anti-Inflammatory Parameters In Dihydrotestosterone-Estradiolvalerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Oguoyibo Josephine S. Repository.mouau.edu.ng: Retrieved Sep 16, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-anti-inflammatory-parameters-in-dihydrotestosterone-estradiolvalerate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-oguoyibo-josephine-s-7-2

MLA 8th

SISAN, OGUOYIBO. "Effect Of Methanol Leaf Extract Of Annona Muricata On Anti-Inflammatory Parameters In Dihydrotestosterone-Estradiolvalerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Oguoyibo Josephine S" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 14 Aug. 2024, https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-anti-inflammatory-parameters-in-dihydrotestosterone-estradiolvalerate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-oguoyibo-josephine-s-7-2. Accessed 16 Sep. 2024.

MLA7

SISAN, OGUOYIBO. "Effect Of Methanol Leaf Extract Of Annona Muricata On Anti-Inflammatory Parameters In Dihydrotestosterone-Estradiolvalerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Oguoyibo Josephine S". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 14 Aug. 2024. Web. 16 Sep. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-anti-inflammatory-parameters-in-dihydrotestosterone-estradiolvalerate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-oguoyibo-josephine-s-7-2 >.

Chicago

SISAN, OGUOYIBO. "Effect Of Methanol Leaf Extract Of Annona Muricata On Anti-Inflammatory Parameters In Dihydrotestosterone-Estradiolvalerate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Oguoyibo Josephine S" Repository.mouau.edu.ng (2024). Accessed 16 Sep. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-leaf-extract-of-annona-muricata-on-anti-inflammatory-parameters-in-dihydrotestosterone-estradiolvalerate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-oguoyibo-josephine-s-7-2

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