Effect of methanol extract ofHibiscus sabdariffa on histopathology and kidney function ofthiacetamide induced toxicity in Wistar albino rats
ABSTRACT
The kidney, which plays a vital role in body
homeostasis and excretion ofmetabolic waste could be affected by the toxicant;
thioacetamide. The aim ofthis study was to investigate the effect of Hibiscus
sabdariffa L. on renal function and kidney histology ofthioacetamide induced
toxicity in wistar albino rats. Twenty (20) wistar albino rats were randomly
divided into five experimental groups of four rats each. Group A: Normal
control group received only normal saline for 7 days orally. Group B: Negative
control group received thioacetamide 2 days prior to start of experiment and
normal saline for 7 days. Group C: Positive control group received
thioacetamide 2 days prior to start of experiment and 50mg/kg body weight of
silymarin for 7 days. Group D: Received thioacetamide 2 days prior to start of
experiment and 250mg/kg body weight of extract for 7 days. GROUP E: Received
thioacetamide 2 days prior to start of experiment and 500mg/kg body weight of
extract for 7 days. All rats were humanely sacrificed after overnight fast and
blood harvested via jugular vein and examined for renal biochemical indices and
histology using standard protocol. Results indicated increased urea and
creatinine and mild mesangial fibrosis and interstitial haemmorrhage in thioacetamide
treated rats possibly indicating a disruption of renal tissue integrity.
However silymarin and extract-treated rats showed reduced urea and creatinine
and preserved renal tissue similar to Normal control. The study indicates that
while thioacetamide is possibly reno-toxic, Hibiscus sabdariffa may contain
properties that may ameliorate thioacetamide-induced renal toxicity.
0.0
HENRY, C (2023). Effect of methanol extract ofHibiscus sabdariffa on histopathology and kidney function ofthiacetamide induced toxicity in Wistar albino rats. Repository.mouau.edu.ng: Retrieved Nov 25, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-ofhibiscus-sabdariffa-on-histopathology-and-kidney-function-ofthiacetamide-induced-toxicity-in-wistar-albino-rats-7-2
CHUKWUNONSO, HENRY. "Effect of methanol extract ofHibiscus sabdariffa on histopathology and kidney function ofthiacetamide induced toxicity in Wistar albino rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 16 Oct. 2023, https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-ofhibiscus-sabdariffa-on-histopathology-and-kidney-function-ofthiacetamide-induced-toxicity-in-wistar-albino-rats-7-2. Accessed 25 Nov. 2024.
CHUKWUNONSO, HENRY. "Effect of methanol extract ofHibiscus sabdariffa on histopathology and kidney function ofthiacetamide induced toxicity in Wistar albino rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 16 Oct. 2023. Web. 25 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-ofhibiscus-sabdariffa-on-histopathology-and-kidney-function-ofthiacetamide-induced-toxicity-in-wistar-albino-rats-7-2 >.
CHUKWUNONSO, HENRY. "Effect of methanol extract ofHibiscus sabdariffa on histopathology and kidney function ofthiacetamide induced toxicity in Wistar albino rats" Repository.mouau.edu.ng (2023). Accessed 25 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-ofhibiscus-sabdariffa-on-histopathology-and-kidney-function-ofthiacetamide-induced-toxicity-in-wistar-albino-rats-7-2