Effect of methanol extract of Moringa oleifera and Ocimum gratissimum on protein glycation, liver glycogen and glucose-6-phosphatase activity in nomo-glycemic rat:- Ughelu, Cynthia O.
ABSTRACT
The methanol extracts of Moringa
oleifera and Ocimum gratissimum were investigated for their effects on protein
glycation. liver glycogen and glucose-6-phosphatase activity using Normo
glycemic albino rats. Thirty four male albino rats were used and were randomly
assigned into 6 groups; 6 rats in the groups 1-4 and 5 in groups 5 and 6. Group
I and 2 rats were administered high and low doses of the Ocimum gratissimum
extract respectively, group 3 and 4 rats were administered high and low doses
of the Moringa oleifera extract respectively, group 5 was the drug control
(metformin) and group 6, the normal control. The rats were sacrificed after 30
days of extract administration and their bloods and organs collected to
determine the effect of the extracts on the parameters listed above.
Glucose-6-phosphatase activity and protein glycation concentration of the test
groups showed no significant difference in relation tn the control group but
the high dose of Ocimum gratissimum showed a significance difference from the
control group for the liver glycogen estimation. These findings suggest that
the plant extracts have no effect on the parameters listed above in a normo-glycemic
system and that high dose of Ocimum gratissimum has a lowering effect on liver
glycogen concentration in a nomo-lycemic system.
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UGHELU, O (2024). Effect of methanol extract of Moringa oleifera and Ocimum gratissimum on protein glycation, liver glycogen and glucose-6-phosphatase activity in nomo-glycemic rat:- Ughelu, Cynthia O.. Repository.mouau.edu.ng: Retrieved Dec 26, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-moringa-oleifera-and-ocimum-gratissimum-on-protein-glycation-liver-glycogen-and-glucose-6-phosphatase-activity-in-nomo-glycemic-rat-ughelu-cynthia-o-7-2
OZIOMA, UGHELU. "Effect of methanol extract of Moringa oleifera and Ocimum gratissimum on protein glycation, liver glycogen and glucose-6-phosphatase activity in nomo-glycemic rat:- Ughelu, Cynthia O." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 09 Jan. 2024, https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-moringa-oleifera-and-ocimum-gratissimum-on-protein-glycation-liver-glycogen-and-glucose-6-phosphatase-activity-in-nomo-glycemic-rat-ughelu-cynthia-o-7-2. Accessed 26 Dec. 2024.
OZIOMA, UGHELU. "Effect of methanol extract of Moringa oleifera and Ocimum gratissimum on protein glycation, liver glycogen and glucose-6-phosphatase activity in nomo-glycemic rat:- Ughelu, Cynthia O.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 09 Jan. 2024. Web. 26 Dec. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-moringa-oleifera-and-ocimum-gratissimum-on-protein-glycation-liver-glycogen-and-glucose-6-phosphatase-activity-in-nomo-glycemic-rat-ughelu-cynthia-o-7-2 >.
OZIOMA, UGHELU. "Effect of methanol extract of Moringa oleifera and Ocimum gratissimum on protein glycation, liver glycogen and glucose-6-phosphatase activity in nomo-glycemic rat:- Ughelu, Cynthia O." Repository.mouau.edu.ng (2024). Accessed 26 Dec. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-moringa-oleifera-and-ocimum-gratissimum-on-protein-glycation-liver-glycogen-and-glucose-6-phosphatase-activity-in-nomo-glycemic-rat-ughelu-cynthia-o-7-2