Effect Of Methanol Extract Of Hibiscus Sabdariffa Calyx Extract On Kidney Function Of Thioacetamide Induced Toxicity In Wistar Albino Rats
ABSTRACT
The kidney, which plays a vital
role in body homeostasis and excretion of metabolic waste could be affected by
the toxicant; thioacetamide. The aim of this study was to investigate the
effect of Hibiscus sabdarffa L. on renal function and kidney histology of
thioacetamide induced toxicity in wistar albino rats. Twenty (20) wistar albino
rats were randomly divided into five experimental groups of four rats each.
Group A: Normal control group received only normal saline for 7 days orally.
Group B: Negative control group received thioacetamide 2 days prior to start of
experiment and normal saline for 7 days. Group C: Positive control group
received thioacetamide 2 days prior to start of experiment and 50mg/kg body
weight of silymarin for 7 days. Group D: Received thioacetamide 2 days prior to
start of experiment and 250mg/kg body weight of extract for 7 days. GROUP E:
Received thioacetamide 2 days prior to start of experiment and 500mg/kg body
weight of extract for 7 days. All rats were humanely sacrificed after overnight
fast and blood harvested via jugular vein and examined for renal biochemical
indices and histology using standard protocol. Results indicated increased urea
and creatinine and fibrosis and interstitial haemmorrhage in thioacetamide
treated rats possibly indicating a disruption of renal tissue integrity.
However silymarin and extract-treated rats showed reduced urea and creatinine
and preserved renal tissue similar to Normal control. The study indicates that
while thioacetamide is possibly reno-toxic, Hibiscus sabdarffa may contain
properties that may ameliorate thioacetamide-induced renal toxicity.
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OGBODO, C (2021). Effect Of Methanol Extract Of Hibiscus Sabdariffa Calyx Extract On Kidney Function Of Thioacetamide Induced Toxicity In Wistar Albino Rats . Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-hibiscus-sabdariffa-calyx-extract-on-kidney-function-of-thioacetamide-induced-toxicity-in-wistar-albino-rats-7-2
CHUKWUNONSO, OGBODO. "Effect Of Methanol Extract Of Hibiscus Sabdariffa Calyx Extract On Kidney Function Of Thioacetamide Induced Toxicity In Wistar Albino Rats " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 13 Jul. 2021, https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-hibiscus-sabdariffa-calyx-extract-on-kidney-function-of-thioacetamide-induced-toxicity-in-wistar-albino-rats-7-2. Accessed 24 Nov. 2024.
CHUKWUNONSO, OGBODO. "Effect Of Methanol Extract Of Hibiscus Sabdariffa Calyx Extract On Kidney Function Of Thioacetamide Induced Toxicity In Wistar Albino Rats ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 13 Jul. 2021. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-hibiscus-sabdariffa-calyx-extract-on-kidney-function-of-thioacetamide-induced-toxicity-in-wistar-albino-rats-7-2 >.
CHUKWUNONSO, OGBODO. "Effect Of Methanol Extract Of Hibiscus Sabdariffa Calyx Extract On Kidney Function Of Thioacetamide Induced Toxicity In Wistar Albino Rats " Repository.mouau.edu.ng (2021). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-hibiscus-sabdariffa-calyx-extract-on-kidney-function-of-thioacetamide-induced-toxicity-in-wistar-albino-rats-7-2