ABSTRACT
Benign prostatic hyperplasia (BPH) is an
age-related disease of unknown aetiology characterized by prostatic enlargement
coincident with distinct alterations in tissue histomorphology. Instead of
therapeutic agents that can cause severe side effects, plant extracts are
frequently used to treat BPH. In this study, the phytochemical composition of
C. esculenta and effect of methanol extract of Colocasia esculenta on male
hormonal in dihydrosterone estradiol valarate induced-BPH in male wistar albino
rats. A total of 20 male wistar albino rats and 18 mice were used for this
study. The rats were grouped into 5 groups (n=4). Group I = normal control,
group 2 = BPH-induced, group 3 = received fanisteride, groups 4 and 5 received
200 mg/kg and 400 mg/kg bwt of C. esculenta, respectively. The phytochemical
analysis showed the presence of alkaloids, flavonoids, oxalates, saponins,
tannins, terpenes, glycosides and phenols. The acute toxicity studies using
mice model showed that the methanol extract of the plant was safe at 5000 mg/kg
bwt. The result of this work showed that the disease control group has a
significant (p<0.05) higher level of estradiol when compared with the normal
control group. Prostatic specific antigen (PSA) and testosterone levels significantly
(p<0.05) increased in the control when compared with the normal control and
treatment groups. The result of LH shows that it significantly (p<0.05)
decreased in the disease control when compared with other treatment groups and
normal control groups. There was no significant (p>0.05) difference
(p>0.0 5) in relative organ weight of lungs, kidney and heart but a
significant (p<0.05) decrease in relative weight of liver of the normal
control and groups treated with methanol extract of C. esculento seed. The
result also showed that the relative prostate weight increased significantly
(p<0.05) in disease control relative to other treatment groups while re I at
ive testes weight sign ifican ti y (p<0. 05) decreased in disease contra I
relative to other groups. The decrease in PSA and relative prostate weight
shows that the extract could be used in the management of BPH and can serve as
a source of herbal drug based on the presence of the phytochemicals contained
in it.
UMEANO, S (2024). Effect Of Methanol. Extract Of Colocasia Esculenta On Male Hormone Profile In Dihydrotestosterone Estradiolvalarate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:-Umeano, Edozie S.. Repository.mouau.edu.ng: Retrieved Sep 08, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-colocasia-esculenta-on-male-hormone-profile-in-dihydrotestosterone-estradiolvalarate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-umeano-edozie-s-7-2
SOMTO, UMEANO. "Effect Of Methanol. Extract Of Colocasia Esculenta On Male Hormone Profile In Dihydrotestosterone Estradiolvalarate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:-Umeano, Edozie S." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 09 Jan. 2024, https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-colocasia-esculenta-on-male-hormone-profile-in-dihydrotestosterone-estradiolvalarate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-umeano-edozie-s-7-2. Accessed 08 Sep. 2024.
SOMTO, UMEANO. "Effect Of Methanol. Extract Of Colocasia Esculenta On Male Hormone Profile In Dihydrotestosterone Estradiolvalarate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:-Umeano, Edozie S.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 09 Jan. 2024. Web. 08 Sep. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-colocasia-esculenta-on-male-hormone-profile-in-dihydrotestosterone-estradiolvalarate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-umeano-edozie-s-7-2 >.
SOMTO, UMEANO. "Effect Of Methanol. Extract Of Colocasia Esculenta On Male Hormone Profile In Dihydrotestosterone Estradiolvalarate Induced Benign Prostatic Hyperplasia In Male Wistar Rats:-Umeano, Edozie S." Repository.mouau.edu.ng (2024). Accessed 08 Sep. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-colocasia-esculenta-on-male-hormone-profile-in-dihydrotestosterone-estradiolvalarate-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-umeano-edozie-s-7-2