ABSTRACT

The effect of aqueous fraction of Vernonia amygdalina on lipid profile of rats fed a high fat dieatherosclerosis and myocardial infraction. Studies have shown animals were fasted overnight and sacrificed. Blood profile was assayed using kits supplied by Agappc diagnostics Switzerland. SPSS (Version 20.0) was used for data analysis. Results showed significant (P<0.05) decrease of LDL-cholesterol in groups that received HFD+aqueous fraction of Vernonia amygdalina (98.68+ 20.73) and HFD+Orlistat (65.19±31.19) relative to group that received HFD only received HFD + aqueous fraction (51.16±20.07) and HFD + Orlistat (68.02+16.92) relative to elevated in groups that received HFD + aqueous fraction (220.75±22.27) and HFD + Orlistat significant (P>0.05) decrease in cholesterol level in groups that received HFD + aqueous fraction (127.77+5.05) and HFD + Orlistat (205.37±7.41) when compared with the control HFD group aqueous fraction group when compared to the HFD only group. Relative liver weight was not significant viii \ i used four this study. They were divided into four groups of 6 animals each. Group 1 received Low Fat Diet (LFD), group 2 received High Fat Diet with Orlistat, group 3 received High fat Diet (HFD) only, while group 4 received High Fat Diet with aqueous fraction of Vernonia amygdalina orally t. 200mg/kg body weight for 7 days. The (126.57±5.05) relative to group that received HFD only.(104.13± 13.15). However, there was no the role of Vernonia an. was collected by cardiac puncture. Lipid’ cardiovascular diseases such as lhe effect of aqueous fraction of Vernonia amygdalina on lipid profile of rats fed a high fat diet was investigated. Hyperlipidemia is 'lygdalina in the prevention and management