ABSTRACT
Prostate diseases affect the prostate
gland and are common cause of morbidity in adult men globally. In the light of
this, the effects of biochemical and immuno- hematological indices on prostatic
patients were evaluated in a total of sixty (60) patients aged 40 – 80 years
seen in Abia State University teaching hospital Aba. They were stratified into
three groups: Group 1, 30 prostatitis patients, Group 2 were 20 BPH and group 3
were 10 prostate cancer patients. 50 were control subjects (40 -80 years) were
made up of apparently healthy males. Blood samples were collected and the
following parameters were evaluated red blood cell lipid profiles (total –
cholesterol, LDL –C, HDL –C, TAG –C, Phospholipids, antioxidants(uric acid,
SOD, GPX, total and conjugated bilirubin, xanthine oxidase, NADPH
oxidase, trace elements(copper, iron, lead, manganese, zinc, selenium)
hematological profile (hemoglobin, PCV,WBC- total and differentials, RBC,
platelets, MCH, MCV, MCHC, lymphocytes, monocytes, granulocytes, bleeding time,
clotting time), immunological markers (troponins, LDH, CPK, TNF, interleukin,
globulin, alpha – macroglobulin, antitrypsin), anthropometric markers( height, weight,
body mass index) and blood sugar. Results showed that t–cholesterol, LDL –C,
TAG –C, phospholipids of prostatic patients increased significantly (p<0.05)
compared to control subjects whereas HDL – C of prostatic patients decreased
significantly (p<0.05) compared to control subjects. Zinc and Selenium levels of prostatic
patients were significantly reduced compared to control subjects. Iron and lead
levels showed no significant difference in prostatic patients compared to
control patients (p>0.05). Manganese levels was significantly increased in
BPH patients compared to control subjects while manganese levels of prostatitis
and prostate cancer (PC) patients showed no significant reduction compared to
control subjects. Copper levels of prostatic patients reduced significantly
compared to control subjects. HB, PCV, WBC-total and differentials,
lymphocytes, granulocytes, MCHC showed no significant difference compared to
control subjects whereas RBC, platelets MCV, bleeding and clotting time levels
of prostatic patients showed significant reduction compared to control
subjects. Uric acid levels of prostatitis patients increased significantly
compared to control subjects whereas there was no significant increase in BPH
and prostatic cancer patients when compared to control subjects. SOD, GPX
and XOD oxidase levels of prostatic patients showed significant reduction
compared with control subjects. Total and conjugated – bilirubin and NADPH
oxidase levels of prostatic patients showed no significant difference when
compared to control subjects. Globulin, alpha- macroglobulin, antitrypsin
showed significant increase compared to control subjects. FSH and LH levels
showed significant reduction compared to control subjects while there was significant
increase in testosterone of prostatic patients compared to control subjects.
PSA levels in prostatic patients showed significant increase compared to
control subjects. Troponin, LDH, and CPK levels increased significantly
compared to control subjects. Ht, Wt, BMI and blood sugar levels of prostatic
patients showed no significant difference compared to control subjects. We
therefore conclude that these changes may be important in pathogenesis of
prostate diseases and uric acid levels
appears to be a key player in inflammation and emerging biochemical marker
for diagnosis of prostatic diseases.
Keywords: Benign prostatic hyperplasia, Prostate cancer, prostatitis.
AGBUGBA, A (2024). ꞌꞌComparative Evaluation of Biochemical and Immuno – hematological profiles of prostatic diseases patients of Abia State University teaching hospital (ABSUTH) Aba, Abia Stateꞌꞌ:- Agbugba, Agnes N. Repository.mouau.edu.ng: Retrieved Sep 07, 2024, from https://repository.mouau.edu.ng/work/view/comparative-evaluation-of-biochemical-and-immuno-hematological-profiles-of-prostatic-diseases-patients-of-abia-state-university-teaching-hospital-absuth-aba-abia-state-agbugba-agnes-n-7-2
AGBUGBA, AGBUGBA. "ꞌꞌComparative Evaluation of Biochemical and Immuno – hematological profiles of prostatic diseases patients of Abia State University teaching hospital (ABSUTH) Aba, Abia Stateꞌꞌ:- Agbugba, Agnes N" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 17 Jul. 2024, https://repository.mouau.edu.ng/work/view/comparative-evaluation-of-biochemical-and-immuno-hematological-profiles-of-prostatic-diseases-patients-of-abia-state-university-teaching-hospital-absuth-aba-abia-state-agbugba-agnes-n-7-2. Accessed 07 Sep. 2024.
AGBUGBA, AGBUGBA. "ꞌꞌComparative Evaluation of Biochemical and Immuno – hematological profiles of prostatic diseases patients of Abia State University teaching hospital (ABSUTH) Aba, Abia Stateꞌꞌ:- Agbugba, Agnes N". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 17 Jul. 2024. Web. 07 Sep. 2024. < https://repository.mouau.edu.ng/work/view/comparative-evaluation-of-biochemical-and-immuno-hematological-profiles-of-prostatic-diseases-patients-of-abia-state-university-teaching-hospital-absuth-aba-abia-state-agbugba-agnes-n-7-2 >.
AGBUGBA, AGBUGBA. "ꞌꞌComparative Evaluation of Biochemical and Immuno – hematological profiles of prostatic diseases patients of Abia State University teaching hospital (ABSUTH) Aba, Abia Stateꞌꞌ:- Agbugba, Agnes N" Repository.mouau.edu.ng (2024). Accessed 07 Sep. 2024. https://repository.mouau.edu.ng/work/view/comparative-evaluation-of-biochemical-and-immuno-hematological-profiles-of-prostatic-diseases-patients-of-abia-state-university-teaching-hospital-absuth-aba-abia-state-agbugba-agnes-n-7-2