Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus:- Eze, Kingsley C
ABSTRACT
Crude
methanolic extract of Parkia Biglohosa leaves at 250mg/kg was evaluated for the
antidiabetic activity using streptozotocin induced diabetic rats. The
anti-diabetic drug metformin was used as a standard drug. The plant extract was
able to restore the serum Iron levels to normal blood Hb , while administration
of the standard drug metformin caused a slight shift (p<0.05) from the normal
control. The plant extract P. Biglobosa, and the standard drug (300mg/kg)
restored the blood glucose level to normal. The plant extract was very
effective in keeping the total Hb level in the normal range. The plant extract
reduced the level ofpassing ofurine bringing it to normal range. The plant
extract (250 and mg/kg) showed an effective hypogylcaemic property as judged
from the result of the analysis on the biomarkers -Haemoglobin(Hb), Glycated
Haemoglobin (HbAlc), Liver glycogen, Hexokinase activity, Oral glucose
tolerance test and fasting blood sugar
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EZE, E (2024). Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus:- Eze, Kingsley C. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/antidiabetic-activity-of-crude-methanolic-extract-of-stem-bark-of-parkia-biglobosa-in-type-2-animal-model-diabetes-mellitus-eze-kingsley-c-7-2
EZE, EZE. "Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus:- Eze, Kingsley C" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 29 Feb. 2024, https://repository.mouau.edu.ng/work/view/antidiabetic-activity-of-crude-methanolic-extract-of-stem-bark-of-parkia-biglobosa-in-type-2-animal-model-diabetes-mellitus-eze-kingsley-c-7-2. Accessed 24 Nov. 2024.
EZE, EZE. "Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus:- Eze, Kingsley C". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 29 Feb. 2024. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/antidiabetic-activity-of-crude-methanolic-extract-of-stem-bark-of-parkia-biglobosa-in-type-2-animal-model-diabetes-mellitus-eze-kingsley-c-7-2 >.
EZE, EZE. "Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus:- Eze, Kingsley C" Repository.mouau.edu.ng (2024). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/antidiabetic-activity-of-crude-methanolic-extract-of-stem-bark-of-parkia-biglobosa-in-type-2-animal-model-diabetes-mellitus-eze-kingsley-c-7-2