Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus
ABSTRACT
Crude methanolic extract of Park/a Biglobosa leaves at 250mg/kg was evaluated for the antidiabetic activity using streptozotocin induced diabetic rats. The anti-diabetic drug metformin was used as a standard drug. The plant extract was able to restore the serum Iron levels to normal blood Hb , while administration of the standard drug metformin caused a slight shift (p<O.05) from the normal control. The plant extract P. Biglohosa, and the standard drug (300mg/kg) restored the blood glucose level to normal. The plant extract was very effective in keeping the total Hb level in the normal range. The plant extract reduced the level of passing of urine bringing it to normal range. The plant extract (250 and mg/kg showed an effective hypogylcaemic property as judged from the result of the analysis on the biomarkers — Haemogiobin(Hb), Glycated Haemogiobin (HbA1c), Liver glycogen, Hexokinase activity, Oral glucose tolerance test and fasting blood sugar.
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EZE, C (2021). Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/antidiabetic-activity-of-crude-methanolic-extract-of-stem-bark-of-parkia-biglobosa-in-type-2-animal-model-diabetes-mellitus-7-2
C, EZE. "Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 25 Jun. 2021, https://repository.mouau.edu.ng/work/view/antidiabetic-activity-of-crude-methanolic-extract-of-stem-bark-of-parkia-biglobosa-in-type-2-animal-model-diabetes-mellitus-7-2. Accessed 24 Nov. 2024.
C, EZE. "Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 25 Jun. 2021. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/antidiabetic-activity-of-crude-methanolic-extract-of-stem-bark-of-parkia-biglobosa-in-type-2-animal-model-diabetes-mellitus-7-2 >.
C, EZE. "Antidiabetic Activity Of Crude Methanolic Extract Of Stem Bark Of Parkia Biglobosa In Type 2 Animal Model Diabetes Mellitus" Repository.mouau.edu.ng (2021). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/antidiabetic-activity-of-crude-methanolic-extract-of-stem-bark-of-parkia-biglobosa-in-type-2-animal-model-diabetes-mellitus-7-2