ABSTRACT

The effect of administration of methanol extract of Citrulluslanatus seed on hematological parameters, body weight and relative organ weight was studied in Benign prostatic hyperplasia (BPH) induced male Albino Rats. Phytochemical and acute toxicity study was conducted on the seed of Citrulluslanatususing standard methods. Thirty six ratswere divided into five experimental groups of 6 rats each; Group 1- normal control, Group 2- disease control (BPHgroup), Group 3- standard drugs control (finasteride-group), Group 4 and 5(200 and 400 mg/kg : of Citrulluslanatusextiact respectively). The NC was not induced with BPH but was given olive oil administered orally (everyday)and subcutaneous injection of olive oil (every other day) for 28 days. The disease control group was induced BPH hormones every other day for 28 days and oral administration of olive oil for 28 days. The standard control group (induced BPH) was givenfinasteride 5mg/70kg administered orally everyday. The 200mg/kg and 400mg/kg of methanol extract of Citrulluslanatusseed. was given to BPH induced rats orally every day respectively. Results of the phytochemical studies showed high levels offlavonoids (2.17 ±0.014mg/100g),followed by, saponins (2.11 ± 0.014mg/100g) and reducing sugar (1.615 ± 0.212mg/100g).Cyanogenicglycoside (0.04 ± 0.007mg/100g) has the lowest concentration. The result also showed that PSA levels decreased significantly (P<0.05) in groups treated with different doses of Citrulluslanatusextract. Body weight, HB, PCV and WBC significant (P< 0.05) increase in treated BPH rats compared to non treated diseased group.No significant difference (P>0.05) was observed for RBC of all the experimental groups when compared with the control. The WBC has a significant increase when treated with 400mg/kg Citrulluslanatus seed compared with normal control rats. The MCV, MCH, and MCHC showed a significantly increases when treated with Citrulluslanatus extract when compared with normal. This study reveals important phytochemical constituent which shows that Citrulluslanatus may have beneficial effect in preventing or suppressing the development of BPH and useful in treatment and management.