ABSTRACT
The effect of Hibiscus sabdariffa
extract on Lipid profile parameters was studied in Thioacetamide intoxicated
Wister rats. The sample of fresh leaves of Hibiscus sabdariffa were dried,
grinded and am extraction was done on it with the use of ethanol and water
(aqueous) and the extract was used in treating thioacetamide intoxicated rats,
since the thioacetamide caused hypatotoxicity in the rats. The rats were in
five groups, each group has five rats. Group one was under control with just
feed and water, group two was administered with thioacetamide, group three was
administered with thioaceamide and sylmarine, group four was administered with
thioacetamide and low Hibiscus sabdariffa extract (250mg/kg), group five was
administered with thioacetamide and high Hibiscus sabdariffa extract
(500mg/kg). After the administration, the rats were sacrificed through cardiac
puncture and the blood was taken and was used for the analysis to determine the
following lipid profile parameters; triglyceride, cholesterol, low-density
lipoprotein and high-density lipoprotein. In triglyceride, the group one, group
two and group four rats have significant increase with the values 47,93±0.43,
45.63±1.83 and 40.58±0.53 respectively and group three and five rats have
significant decrease with the values 30.19±0.39 and 36.25±1.5 respectively.
There was also a significant increase in group one, two and four rats in
cholesterol and low-density lipoprotein and significant decrease in group three
and five rats in cholesterol and low-density lipoprotein. In highdensity
lipoprotein, there was a significant decrease in group one and two with the
values 4.18±0.05 and 3.5±0.15 and a significant increase in group three, four
and five with the values 10.16±0.33, 8.83±0.14 and 6.83±0.14 respectively. This
result deduced that the Hibiscus sabdariffa extract possess hepato regenerative
properties which significantly reduce lipid profile levels of some parameters
which thioacetamide made high like triglyceride, cholesterol and lowdensity
lipoprotein and it also increase high-density lipoprotein level since the
thioacetamide made it to be low. This study proves that Hibiscus sabdariffa
extract has the ability to reduce hepatotoxicity although it is not effective
as the use of sylmarine
ADA, U (2024). The Effect Of Hibiscus Sabdariffa Extract On Lipid Profile Parameters Of Thioacet Amide Intoxicated Wister Rats:- Ukpo, Ada U.. Repository.mouau.edu.ng: Retrieved Sep 08, 2024, from https://repository.mouau.edu.ng/work/view/the-effect-of-hibiscus-sabdariffa-extract-on-lipid-profile-parameters-of-thioacet-amide-intoxicated-wister-rats-ukpo-ada-u-7-2
UDUMA, ADA. "The Effect Of Hibiscus Sabdariffa Extract On Lipid Profile Parameters Of Thioacet Amide Intoxicated Wister Rats:- Ukpo, Ada U." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 09 Jan. 2024, https://repository.mouau.edu.ng/work/view/the-effect-of-hibiscus-sabdariffa-extract-on-lipid-profile-parameters-of-thioacet-amide-intoxicated-wister-rats-ukpo-ada-u-7-2. Accessed 08 Sep. 2024.
UDUMA, ADA. "The Effect Of Hibiscus Sabdariffa Extract On Lipid Profile Parameters Of Thioacet Amide Intoxicated Wister Rats:- Ukpo, Ada U.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 09 Jan. 2024. Web. 08 Sep. 2024. < https://repository.mouau.edu.ng/work/view/the-effect-of-hibiscus-sabdariffa-extract-on-lipid-profile-parameters-of-thioacet-amide-intoxicated-wister-rats-ukpo-ada-u-7-2 >.
UDUMA, ADA. "The Effect Of Hibiscus Sabdariffa Extract On Lipid Profile Parameters Of Thioacet Amide Intoxicated Wister Rats:- Ukpo, Ada U." Repository.mouau.edu.ng (2024). Accessed 08 Sep. 2024. https://repository.mouau.edu.ng/work/view/the-effect-of-hibiscus-sabdariffa-extract-on-lipid-profile-parameters-of-thioacet-amide-intoxicated-wister-rats-ukpo-ada-u-7-2