Studies On The Effect Of Ethanol Extract Of Bridelia Scleroneura Leaf On Fe2+/Fe3+ Ratio, Solubility And Osmotic Fragility Of Sickle Erythrocytes:- Isikaku, Nmesomachi S
ABSTRACT
Medicinal
plants are plants that have a recognized medical use. They range from those
used in the production of mainstream pharmaceutical products to plants used in
herbal medicine preparations values. The aim ofthis study is to determine the
effect of ethanol extract of Bridelia scleroneura leaf on Fe2+/Fe3+ ratio,
solubility and osmotic fragility of sickle erythrocytes. Bridelia scleroneura
leaves were air-dried into coarse powder. The results showed that the ethanol
extract of Bridelia scleroneura leaf significantly (P < 0.05) inhibited
sickling at all concentrations with the highest percentage inhibition of
76.67%, reversed sickled erythrocytes at all concentrations with the highest
percentage reversal of 63.3% and significantly (P < 0.05) inhibited
polymerization at all concentrations used in comparison to the parallel
control. Result indicated that there was a significant increase (p<0.05) in
membrane-stability of Sickle RBC and) and osmotic fragility (at 50% and 25%
concentrations) and a decrease in solubility (P > 0.05) when compared with parallel
control. The results indicate the anti-sickling potential of ethanol extract
ofBridelia scleroneura leaf
0.0
ISIKAKU, I (2024). Studies On The Effect Of Ethanol Extract Of Bridelia Scleroneura Leaf On Fe2+/Fe3+ Ratio, Solubility And Osmotic Fragility Of Sickle Erythrocytes:- Isikaku, Nmesomachi S. Repository.mouau.edu.ng: Retrieved Dec 22, 2024, from https://repository.mouau.edu.ng/work/view/studies-on-the-effect-of-ethanol-extract-of-bridelia-scleroneura-leaf-on-fe2fe3-ratio-solubility-and-osmotic-fragility-of-sickle-erythrocytes-isikaku-nmesomachi-s-7-2
ISIKAKU, ISIKAKU. "Studies On The Effect Of Ethanol Extract Of Bridelia Scleroneura Leaf On Fe2+/Fe3+ Ratio, Solubility And Osmotic Fragility Of Sickle Erythrocytes:- Isikaku, Nmesomachi S" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 13 Nov. 2024, https://repository.mouau.edu.ng/work/view/studies-on-the-effect-of-ethanol-extract-of-bridelia-scleroneura-leaf-on-fe2fe3-ratio-solubility-and-osmotic-fragility-of-sickle-erythrocytes-isikaku-nmesomachi-s-7-2. Accessed 22 Dec. 2024.
ISIKAKU, ISIKAKU. "Studies On The Effect Of Ethanol Extract Of Bridelia Scleroneura Leaf On Fe2+/Fe3+ Ratio, Solubility And Osmotic Fragility Of Sickle Erythrocytes:- Isikaku, Nmesomachi S". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 13 Nov. 2024. Web. 22 Dec. 2024. < https://repository.mouau.edu.ng/work/view/studies-on-the-effect-of-ethanol-extract-of-bridelia-scleroneura-leaf-on-fe2fe3-ratio-solubility-and-osmotic-fragility-of-sickle-erythrocytes-isikaku-nmesomachi-s-7-2 >.
ISIKAKU, ISIKAKU. "Studies On The Effect Of Ethanol Extract Of Bridelia Scleroneura Leaf On Fe2+/Fe3+ Ratio, Solubility And Osmotic Fragility Of Sickle Erythrocytes:- Isikaku, Nmesomachi S" Repository.mouau.edu.ng (2024). Accessed 22 Dec. 2024. https://repository.mouau.edu.ng/work/view/studies-on-the-effect-of-ethanol-extract-of-bridelia-scleroneura-leaf-on-fe2fe3-ratio-solubility-and-osmotic-fragility-of-sickle-erythrocytes-isikaku-nmesomachi-s-7-2