Protective Effect 0f Annona Muricata Linn Aqueous Leaf Extract On Liver Enzymes Of Male Wistar Rats Treated With Used Motor Engine Oil:- Udochukwu Amarachi D
ABSTRACT
The
liver is a vital organ in the body with a wide range of metabolic functions. It
is very important for survival and cannot be compensated for in the absence of
long term liver function. The liver which plays a crucial role in metabolism
also metabolizes heavy metals and when exposed to chemicals which may probably
beheavy metals lauded in used motor engine oil can lead to liver dysfunction,
cell damage and organ failure. An elevation ofliver enzymes like ALT, ASP and
ALP could suggest a liver malfunction. This study was aimed at evaluating the
protective effect ofAnnona Muricata (linn) aqueous leaf extract on AST, ALP and
ASP of male Wistar rats treated with used motor engine oil. Thirty-five male
Wistar rats were randomly distributed into 7 groups of five rats each. Group A
received standard diets, group B received UMEO only, group C and D received
lOOmg/kg and 200mg/kg ofAnnona muricata leaf extract respectively for two weeks
before been treated with UMEO for the remaining two weeks, group E and F
received lOOmg/kg and 200mg/kg respectively of Annona muricata after been
treated with UMEO for the first two weeks while Group G received the standard
drug Vitamin C after receiving UMEO. The experiment lasted for a period of 28
days. There were significant (p<0.05) increase in ALT, AST and ALP levels in
animals treated with UMEO but similarly a significant decrease in AST, ALP and
ASP levels was observed with administration ofthe leaf extract. This study
showed that UMEO is capable of inducing hepatoxicity and Annona Muricata leaf
extract possess hepato-protective ability as increase in liver enzymes were
observed. Lienee, Annona moricata leaf extract may serve in liver treatment
therapies
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MICHAEL, U (2024). Protective Effect 0f Annona Muricata Linn Aqueous Leaf Extract On Liver Enzymes Of Male Wistar Rats Treated With Used Motor Engine Oil:- Udochukwu Amarachi D. Repository.mouau.edu.ng: Retrieved Nov 21, 2024, from https://repository.mouau.edu.ng/work/view/protective-effect-0f-annona-muricata-linn-aqueous-leaf-extract-on-liver-enzymes-of-male-wistar-rats-treated-with-used-motor-engine-oil-udochukwu-amarachi-d-7-2
UNIVERSITY, MICHAEL. "Protective Effect 0f Annona Muricata Linn Aqueous Leaf Extract On Liver Enzymes Of Male Wistar Rats Treated With Used Motor Engine Oil:- Udochukwu Amarachi D" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 10 Oct. 2024, https://repository.mouau.edu.ng/work/view/protective-effect-0f-annona-muricata-linn-aqueous-leaf-extract-on-liver-enzymes-of-male-wistar-rats-treated-with-used-motor-engine-oil-udochukwu-amarachi-d-7-2. Accessed 21 Nov. 2024.
UNIVERSITY, MICHAEL. "Protective Effect 0f Annona Muricata Linn Aqueous Leaf Extract On Liver Enzymes Of Male Wistar Rats Treated With Used Motor Engine Oil:- Udochukwu Amarachi D". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 10 Oct. 2024. Web. 21 Nov. 2024. < https://repository.mouau.edu.ng/work/view/protective-effect-0f-annona-muricata-linn-aqueous-leaf-extract-on-liver-enzymes-of-male-wistar-rats-treated-with-used-motor-engine-oil-udochukwu-amarachi-d-7-2 >.
UNIVERSITY, MICHAEL. "Protective Effect 0f Annona Muricata Linn Aqueous Leaf Extract On Liver Enzymes Of Male Wistar Rats Treated With Used Motor Engine Oil:- Udochukwu Amarachi D" Repository.mouau.edu.ng (2024). Accessed 21 Nov. 2024. https://repository.mouau.edu.ng/work/view/protective-effect-0f-annona-muricata-linn-aqueous-leaf-extract-on-liver-enzymes-of-male-wistar-rats-treated-with-used-motor-engine-oil-udochukwu-amarachi-d-7-2