Evaluation Of Antinociceptive And Anti-Inflammatory Effects Of Pentaclethra Macrophylla (Benth.) Aqueous Extracts In Mice
ABSTRACT
This study was carried out to evaluate the 'cytotoxicity and
the anti-trichomonal, antinociceptive, anti-inflammatory and antimalarial
effects of aqueous extracts of Pentaclethra macrophylla (Benth). The efficacy
of the extracts (fruit-pericarp, bark, leaf and seed) against the flagellate
Trichomonas gallinae was determined by using metronidazole as a reference drug.
The parasite was isolated from the crop of domestic pigeon and incubated for
24hrs. Minimal lethal concentrations (MLCs) of three of the four extracts
(fruit-pericarp, bark and seed) ranged between 100-1 000tg/ml while the
parasite was not sensitive to the leaf extract. The cytotoxicity test revealed
that the bark was highly toxic (256.4p.1) followed by the fruit-pericarp (80.1
p1). In the antinociceptive and anti-inflammatory tests, oedema' formation in
the lungs was significantly (P<0.05) suppressed in seed, fruitpericarp, and leaf extracts. The seed and leaf extracts significantly (P><0.05) suppressed oedema formation in the carrageenin induced right paw oedema test; while the reduction observed in the fruit-pericarp was not significant (P>0.05).
The number of leucocytes counted from the exudates collected in the pleural I
cavity showed a significant
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OKORIE, C (2021). Evaluation Of Antinociceptive And Anti-Inflammatory Effects Of Pentaclethra Macrophylla (Benth.) Aqueous Extracts In Mice. Repository.mouau.edu.ng: Retrieved Apr 26, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-of-antinociceptive-and-anti-inflammatory-effects-of-pentaclethra-macrophylla-benth-aqueous-extracts-in-mice-7-2
CHIDIEBERE, OKORIE. "Evaluation Of Antinociceptive And Anti-Inflammatory Effects Of Pentaclethra Macrophylla (Benth.) Aqueous Extracts In Mice" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 13 Oct. 2021, https://repository.mouau.edu.ng/work/view/evaluation-of-antinociceptive-and-anti-inflammatory-effects-of-pentaclethra-macrophylla-benth-aqueous-extracts-in-mice-7-2. Accessed 26 Apr. 2024.
CHIDIEBERE, OKORIE. "Evaluation Of Antinociceptive And Anti-Inflammatory Effects Of Pentaclethra Macrophylla (Benth.) Aqueous Extracts In Mice". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 13 Oct. 2021. Web. 26 Apr. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-of-antinociceptive-and-anti-inflammatory-effects-of-pentaclethra-macrophylla-benth-aqueous-extracts-in-mice-7-2 >.
CHIDIEBERE, OKORIE. "Evaluation Of Antinociceptive And Anti-Inflammatory Effects Of Pentaclethra Macrophylla (Benth.) Aqueous Extracts In Mice" Repository.mouau.edu.ng (2021). Accessed 26 Apr. 2024. https://repository.mouau.edu.ng/work/view/evaluation-of-antinociceptive-and-anti-inflammatory-effects-of-pentaclethra-macrophylla-benth-aqueous-extracts-in-mice-7-2