Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Red Blood Cell (Rbc) Count Of Indomethacin-Ulcerated Rats:-Nkwocha, Doreen E.
ABSTRACT
Plants
have been the basis for trado-medical treatments through much of human history
and such traditional medicine is still widely in use today such as the leaves
of M. paradisiaca. The objectives of this work were to examine the
phytochemical constituents, acute toxicity and lethality and effect of the
methanol extract of the leaves of M. paradisiaca on red blood cell count of
indomethacin-ulcerated rats. The preliminary phytochemical screening revealed
that the plant leaves contained alkaloids, flavonoids, tannins, saponins,
carbohydrates, reducing sugars, proteins, steroids, terpenoids and fats and oil
but resins, glycosides and acidic compounds were not detected. The extract was
found to be safe at a dose as high as 5000 mg/kg body weight (b.w). The extract
at the tested doses (100, 200 and 400 mg/kgb.w) significantly (p < 0.05) and
dose-dependently increased the red blood cell count ofthe rats in the test groups
when compared to the value obtained for the rats in the ulcer-untreated group.
The effect ofthe 400 mg/kg b.w of the extract was similar to that ofthe
standard anti-ulcer drug, famotidine at the dose of 50 mg/kg b.w. The results
indicate that the methanol extract ofthe leaves of M. paradisiaca contains some
pharmacological active principles which may raise the red blood cell count in
ulcerated rats.
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NKWOCHA, E (2024). Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Red Blood Cell (Rbc) Count Of Indomethacin-Ulcerated Rats:-Nkwocha, Doreen E. . Repository.mouau.edu.ng: Retrieved Dec 26, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musa-paradisiaca-on-the-red-blood-cell-rbc-count-of-indomethacin-ulcerated-rats-nkwocha-doreen-e-7-2
EBERE, NKWOCHA. "Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Red Blood Cell (Rbc) Count Of Indomethacin-Ulcerated Rats:-Nkwocha, Doreen E. " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 20 Feb. 2024, https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musa-paradisiaca-on-the-red-blood-cell-rbc-count-of-indomethacin-ulcerated-rats-nkwocha-doreen-e-7-2. Accessed 26 Dec. 2024.
EBERE, NKWOCHA. "Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Red Blood Cell (Rbc) Count Of Indomethacin-Ulcerated Rats:-Nkwocha, Doreen E. ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 20 Feb. 2024. Web. 26 Dec. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musa-paradisiaca-on-the-red-blood-cell-rbc-count-of-indomethacin-ulcerated-rats-nkwocha-doreen-e-7-2 >.
EBERE, NKWOCHA. "Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Red Blood Cell (Rbc) Count Of Indomethacin-Ulcerated Rats:-Nkwocha, Doreen E. " Repository.mouau.edu.ng (2024). Accessed 26 Dec. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musa-paradisiaca-on-the-red-blood-cell-rbc-count-of-indomethacin-ulcerated-rats-nkwocha-doreen-e-7-2